#81 PCOS, Insulin Resistance & The Hormone Doctors Miss

If you’ve ever been told “your labs look fine” while your body loudly disagrees, this episode is for you. Lori sits down with Dr. Ali Chappell—a nutrition scientist, reproductive endocrinology researcher, and registered dietitian—to reframe PCOS and beyond through the lens of the hormone that most of us never test: insulin. Together, they unpack why A1C can look “normal” while fasting or post-meal insulin runs high; how that blocks ovulation, fuels acne and fatigue, and complicates pregnancy; and why menopause symptoms often escalate when insulin creeps up. Ali breaks down low-insulin living without obsession or calorie counting, clears up the dairy/protein powder debate (yes, we’re looking at you, whey), and shares a simple script for getting your clinician to order the right labs. You’ll walk away with practical food swaps, a clearer map of the metabolism–hormone connection, and—most importantly—more hope.

 
 

Show Notes

Insulin is a key hormone that affects weight and health.

A low insulin lifestyle is more sustainable than traditional dieting.

Not all dairy is harmful; it depends on the type.

Understanding food choices can help manage insulin levels.

Mental health is a significant aspect of living with PCOS.

Effective communication with healthcare providers is crucial.

The Lilly app offers resources for managing PCOS and insulin resistance.

Education about insulin resistance is essential for empowerment.

Lifestyle changes can lead to significant health improvements.

Insulin resistance is a growing concern in modern health discussions.



Summary


In this conversation, Lori Clarke and Ali Chappell delve into the complexities of PCOS, insulin resistance, and their implications for women's health. They discuss the importance of understanding hormonal balances, the role of diet in managing insulin levels, and the need for better education in women's health. The conversation also touches on the impact of menopause and chronic conditions related to insulin resistance, emphasizing the necessity of testing insulin levels for a comprehensive understanding of health. In this enlightening conversation, Dr. Ali Chappell discusses her personal journey with PCOS and the science behind a low insulin lifestyle. She emphasizes the importance of understanding insulin's role in weight management and overall health, while also addressing the nuances of food choices, particularly regarding dairy and carbohydrates. The discussion extends to mental health challenges faced by those with PCOS, the significance of effective communication with healthcare providers, and the introduction of the Lilly app designed to support individuals in managing their condition. Dr. Chappell encourages listeners to empower themselves with knowledge and take actionable steps towards a healthier lifestyle.

 

Learn more about today's guest

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#80 Brandon Lee on Childhood Trauma, Emotional Fluency & Finding Your Genius